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MeDALL is a collaborative project supported by the European Union

medall coordinators


Birth cohorts in asthma and allergic diseases: Report of a NIAID/NHLBI/MeDALL joint workshop

Journal of Allergy Clinical Immunology March 2014


The Development of the MeDALL Core Questionnaires for a Harmonized Follow-Up Assessment of Eleven European Birth Cohorts on Asthma and Allergies

Int Arch Allergy Immunol March 2014

Questionnaires available in the section "MeDALL documents"


Comorbidity of eczema, rhinitis, and asthma in IgE-sensitised and non-IgE-sensitised children in MeDALL: a population-based cohort study

Lancet Respir Med January 2014


Environmental biodiversity, human microbiota, and allergy are interrelated

PNAS May 2012


The Finnish Allergy Programme 2008-2018 - scientific rationale and pratical implementation 

Asia Pacific allergy September 2012


alpha-Purothionin, a new wheat allergen associated with severe allergy

Journal of Allergy Clinical Immunology October 2013


Application of 'omics technologies to biomarker discovery in inflammatory lung diseases

European Respiratory Journal September 2013


Communication of results and disclosure of incidental findings in longitudinal paediatric research

Pediatric Allergy and Immunology June 2013


Suppression of B-cell activation and IgE, IgA, IgG1 and IgG4 production by mammalian telomeric oligonucleotides 

Allergy: European Journal of Allergy and Clinical Immunology May 2013


Triggering of specific Toll-like receptors and proinflammatory cytokines breaks allergen-specific T-cell tolerance in human tonsils and peripheral blood

Journal of Allergy and Clinical Immunology March 2013


Childhood lung function and the association with ?2-adrenergic receptor haplotypes

Paediatrica, Volume 102, Issue 7, pages 727-731, March 2013


Genomic Incidental Findings: Reducing the Burden to Be Fair

American Journal of Bioethics February 2013


Triclosan exposure and allergic sensitization in Norwegian children

Allergy, Volume 68, Issue 1, January 2013


IgG4 production is confined to human IL-10-producing regulatory B cells that suppress antigen-specific immune responses

The Journal of Allergy and Clinical Immunology, April 2013


Impact of early diagnosis and control of chronic respiratory diseases on active and healthy ageing

A debate at the European Union Parliament

The Journal of Allergy and Clinical Immunology, April 2013


Correspondence on the paper by Krauss-Etschmann S, Bush A, Bellusci S, et al.

Published on thorax.bmj.com on April 12, 2013


Defective epithelial barrier in chronic rhinosinusitis: The regulation of tight junctions by IFN-g and IL-4

Journal of Allergy Clinical Immunology June 2012


Early suppression of basophil activation during allergenspecific immunotherapy by histamine receptor

Journal of Allergy Clinical Immunology May 2012 


Mechanisms of IFN-g–induced apoptosis of human skin keratinocytes in patients with atopic dermatitis

Journal of Allergy Clinical Immunology May 2012


The broad spectrum of interepithelial junctions in skin and lung  

Journal of Allergy Clinical Immunology August 2012


Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections     

Journal of Allergy Clinical Immunology March 2012


Allergy in children: practical recommendations of the Finnish Allergy Programme 2008-2018 for prevention, diagnosis, and treatment.

Pediatr Allergy Immunol 2012;23:103-16. February 2012


The Finnish Allergy Programme 2008-2018 - scientific rationale and practical implementation

Asia Pac Allergy 2012;2:275-279 September 2012


Molecular and Immunological Characterization of Tri a 36, a Low Molecular Weight Glutenin, as a Novel Major Wheat Food Allergen

The Journal of Immunology, October 2012


Analysis of serum IgE reactivity profiles with microarrayed allergens indicates absence of de novo IgE sensitizations in adults

The Journal of Allergy and Clinical Immunology, August 2012


Molecular characterization of wheat allergens specifically recognized by patients suffering from wheat-induced respiratory allergy

Clinical & Experimental Allergy, January 2012


Pathophysiology of asthma: lessons from genetic research with particular focus on severe asthma

Journal of Internal Medicine, August 2012


Developing a policy for paediatric biobanks: principles for good practice

European Journal of Human Genetics, June 2012


Therapies for allergic inflammation: refining strategies to induce tolerance

Nature Medicine, May 2012


TH17 and TH22 cells: A confusion of antimicrobial response with tissue inflammation versus protection

Journal of Allergy and Clinical Immunology, May 2012


Ethical, legal and social issues in longitudinal studies involving children: The MeDALL Project

V. Anastosova, A. Mahalatchimy, A. Cambon-Thomsen, In Les Etudes Hospitalières collection  « Séminaire d’actualité de droit médical », Bordeaux 2012, In Press, page 297-309.


Systematic Review Protocol to Define Classical IgE-Associated Diseases from Birth to Adolescence: The MeDALL Study

Article published on WebmedCentral.com in May 2012 (open access)


Environmental biodiversity, human microbiota, and allergy are interrelated

PNAS, April 2012 (open access)


Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) Seminar

Journal of Allergy Clinical Immunology, March 2012


Induction and maintenance of allergen-specific FOXP3+ Treg cells in human tonsils as potential first-line organs of oral tolerance

Journal of Allergy and Clinical Immunology, Februray 2012


Severe chronic allergic (and related) diseases: a uniform approach – a MeDALL-GA²LEN-ARIA Position Paper

International Archives of Allergy and Immunology, 2012


Recent advances in the epigenetics and genomics of asthma

Current Opinion in Allergy and Clinical Immunology, October 2011


Systems medicine and integrated care to combat chronic noncommunicable diseases

Genome Medicine, July 2011, also available here (open access)


MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine

Review paper published in Allergy in December 2010



MeDALL related papers


Haahtela T, von Hertzen L, Valovirta E. National Allergy Program in support of hyposensitization in Finland Duodecim 2011; 127:1283-8 (in Finnish) 


Hakola R, Kauppi P, Leino T, Ojajärvi  A, Pentti J, Oksanen T, Haahtela T, Kivimäki M, Vahtera J. Persistent asthma, comorbid conditions and the risk of work disability: a prospective cohort study Allergy 2011;66:1598-603


Kauppi P, Linna M, Martikainen J, Mäkelä MJ, Haahtela T. Follow-up of the Finnish Asthma Programme 2000-2010: reduction of hospital burden needs risk group rethinking. Thorax 2012


Zhang G, Candelaria P, Mäkelä JM, Khoo SK, Hayden MC, von Hertzen L, Laatikainen T, Vartiainen E, Goldblatt J, Haahtela T, LeSouëf NP. Disparity of innate immunity-related gene effects on asthma and allergy on Karelia. Pediatr Allergy Immunol 2011;22:621-30


Mäkelä MJ, Pelkonen A, Valovirta E, Haahtela T. The challenge of relying the right public health messages in allergy.  Pediatr Allergy Immunol 2012;23:102. Editorial  


Allergy gap between Finnish and Russian Karelia on increase

Accepted for publication in Allergy on 3 December 2010


IgE response to Ascaris lumbricoides in Russian children indicates IgE responses to common environmental allergens

Accepted for publication in Allergy on 8 February 2011